{"id":86314,"date":"2021-04-06T05:19:32","date_gmt":"2021-04-05T13:19:32","guid":{"rendered":"http:\/\/demo.abctix.com\/86314.html"},"modified":"2021-04-06T05:19:32","modified_gmt":"2021-04-05T13:19:32","slug":"%e5%bc%a0%e6%99%93%e4%b8%9c%ef%bc%88%e5%bc%80%e5%a4%a7%e5%ad%a6%e6%95%99%e6%8e%88%ef%bc%89%e4%b8%aa%e4%ba%ba%e7%ae%80%e5%8e%86","status":"publish","type":"post","link":"https:\/\/www.dongwubaike.cn\/fanhao\/86314.html","title":{"rendered":"\u5f20\u6653\u4e1c\uff08\u5f00\u5927\u5b66\u6559\u6388\uff09\u4e2a\u4eba\u7b80\u5386"},"content":{"rendered":"

\u57fa\u672c\u5185\u5bb9<\/h3>\n

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\u3000\u3000\u83b7\u5f97\u6388\u6743\u4e13\u5229<\/p>\n<\/p>\n

\u3000\u30001.\u53f6\u4e3d\u8679,\u5f20\u6653\u4e1c,\u5434\u83b2\u82f1,\u6731\u60e0\u82b3.\u9ad8\u8f6c\u79fb\u503e\u5411\u7684\u4eba\u4e73\u817a\u764c\u7ec6\u80de\u7cfb\u53ca\u5176\u5efa\u7acb\u65b9\u6cd5\uff0c\u83b7\u5f97\u56fd\u5bb6\u53d1\u660e\u4e13\u5229.<\/p>\n<\/p>\n

\u3000\u30002.\u53f6\u4e3d\u8679,\u5f20\u6653\u4e1c,\u79e6\u5bb5\u7136,\u6731\u60e0\u82b3\uff0c\u738b\u6d2a\u8f89.\u4eba\u809d\u764c\u8f6c\u79fb\u4e9a\u514b\u9686\u7ec6\u80de\u7cfb\u53ca\u5176\u5efa\u7acb\u65b9\u6cd5\uff0c\u83b7\u5f97\u56fd\u5bb6\u53d1\u660e\u4e13\u5229.<\/p>\n<\/p>\n

\u3000\u3000:\u4e3b\u8981\u5b66\u672f\u8bba\u6587::<\/p>\n<\/p>\n

\u3000\u3000\u5f20\u6653\u4e1c;\u4e1c\u6960;\u6bb7\u4e3d\u8f89;\u8521\u5a1c;\u9a6c\u5b8f\u6d9b;\u5c24\u5609\u742e;\u5f20\u822a;\u738b\u6d2a\u8f89; He, R;. Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues. JOURNAL OF MEDICAL VIROLOGY<\/p>\n<\/p>\n

\u3000\u3000\u5f20\u6653\u4e1c;\u4e1c\u6960;\u5f20\u822a;\u5c24\u5609\u742e;\u738b\u6d2a\u8f89;\u53f6\u4e3d\u8679. Effects of hepatitis B virus X protein on human telomerase reverse transcriptase expression and activity in hepatoma cel. JOURNAL OF LABORATORY AND CLINICAL MEDICINE<\/p>\n<\/p>\n

\u3000\u3000\u738b\u51e4\u6cfd;\u6c99\u4e3d;\u4e54\u73b2;\u5434\u83b2\u82f1;\u5f20\u6653\u4e1c;\u53f6\u4e3d\u8679. Promotion of transcriptional activity of NF-kappa B mediated by HBXIP in hepatoma cells. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS<\/p>\n<\/p>\n

\u3000\u3000\u79e6\u5bb5\u7136;\u5f20\u822a;\u5468\u6653\u96f7;\u738b\u957f\u6654;\u5f20\u60e0\u4e2d;\u5f20\u6653\u4e1c;\u53f6\u4e3d\u8679. Proliferation and migration mediated by Dkk-1\/Wnt\/beta-catenin cascade in a model of hepatocellular carcinoma cells. TRANSLATIONAL RESEARC<\/p>\n<\/p>\n

\u3000\u3000\u5f20\u6653\u4e1c;\u5f20\u4f1f\u82f1;\u53f6\u4e3d\u8679. Pathogenesis of hepatitis B virus infection. FUTURE VIROLOGY<\/p>\n<\/p>\n

\u3000\u3000\u4e54\u73b2;\u5f90\u6cbb\u7acb;\u8c2d\u65ed;\u53f6\u4e3d\u8679;\u5f20\u6653\u4e1c. Investigation of inhibition of Wnt\/beta-catenin pathway in breast cancer cells mediated by Dkk-1 released from human mesenchymal stem cells. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS<\/p>\n<\/p>\n

\u3000\u3000\u738b\u51e4\u6cfd;\u6c99\u4e3d;\u5f20\u4f1f\u5e94;\u5434\u83b2\u82f1;\u4e54\u73b2;\u674e\u6960;\u5f20\u6653\u4e1c;\u53f6\u4e3d\u8679. Involvement of hepatitis B X-interacting protein (HBXIP) in proliferation regulation of cells. ACTA PHARMACOLOGICA SINICA<\/p>\n<\/p>\n

\u3000\u3000\u5f20\u6653\u4e1c;\u5f20\u822a;\u5434\u83b2\u82f1;\u6c99\u4e3d;\u5218\u6811\u4e1a;\u90b5\u65b0\u534e;\u53f6\u4e3d\u8679. Anti-HBx in sera is a potential marker of development from hepatitis B (HB) to liver cirrhosis (LC) and hepatocellular carcinoma (HCC). JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY<\/p>\n<\/p>\n

\u3000\u3000\u53f6\u4e3d\u8679;\u8521\u5a1c;\u4e1c\u6960;\u674e\u6960;\u5f20\u4f1f\u82f1;\u5f20\u822a;\u5f20\u70dc;\u5434\u83b2\u82f1;\u5f20\u6653\u4e1c. Interference of RNA targeting hepatitis B virus x (HBx) gene reduces the tumorigenicity of hepatoma cells and HBx-transformed human liver cells. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY<\/p>\n<\/p>\n

\u3000\u3000\u5f20\u6653\u4e1c;\u8521\u5a1c;\u674e\u6960;\u5f20\u4f1f\u82f1;\u5f20\u822a;\u5f20\u70dc;\u5434\u83b2\u82f1;\u9f50\u4f17;\u53f6\u4e3d\u8679. Transformation of human normal liver L-O2 cells induced by hepatitis B virus X protein, enhanced by highly expression level of survivin as a co-factor. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY<\/p>\n<\/p>\n

\u3000\u3000Zhang, XD; Zhang, H; Ye, LH. Effects of hepatitis B virus X protein on the development of liver cancer. JOURNAL OF LABORATORY AND CLINICAL MEDICINE 147-2-58.2006-1-1<\/p>\n<\/p>\n

\u3000\u3000Zhang H, Wu LY, Zhang S, Qiu LY, Li N, Zhang X, Zhang XZ, Shan SL, Ye LH, Zhang XD*.Anti-hepatitis B Virus (HBV) X protein (HBx) in sera is one of the markers of development of liver c. J Biomed Biotechnol<\/p>\n<\/p>\n

\u3000\u3000Zhang WY, Cai N, Ye LH, Zhang XD. Transformation of human liver L-O2 cells mediated by stable HBx transfection.. Acta Pharmacol Sinica.<\/p>\n<\/p>\n

\u3000\u3000Zhang WY, Xu FQ, Shan CL, Xiang R, Ye LH, Zhang XD. Gene expression profiles of human liver cells mediated by hepatitis B virus X protein. Acta Pharmacologica Sinica<\/p>\n<\/p>\n

\u3000\u3000You J, Mi D, Zhou X, Qiao L, Xu S, Zhang X, Ye LH. Positive feedback between activated ERK and COX\/LOX contributes to breast cancer cell proliferation . Endocrinology<\/p>\n<\/p>\n

\u3000\u3000Zhou X, Liu Y, You J, Zhang X, Ye LH. Myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1\/2. . Cancer Letters 270–312-327.2008-11-8<\/p>\n<\/p>\n

\u3000\u3000Qiao L, Xu ZL, Zhao TJ, Ye LH, Zhang XD. Dkk-1 secreted by mesenchymal stem cells inhibits growth of breast cancer cells via depression of Wnt signalling. Cancer Letters<\/p>\n<\/p>\n

\u3000\u3000\u5f20\u5b66\u667a,\u5c71\u957f\u4eae,\u53f6\u4e3d\u8679,\u5f20\u6653\u4e1c. RNA\u5e72\u6270\u5728\u6297\u4e59\u809d\u6cbb\u7597\u4e2d\u7684\u5e94\u7528\u53ca\u5176\u7814\u7a76\u8fdb\u5c55. . \u751f\u7269\u5316\u5b66\u4e0e\u751f\u7269\u7269\u7406\u8fdb\u5c55<\/p>\n<\/p>\n

\u3000\u3000Qiao L, Xu Z, Zhao T, Zhao Z, Shi M, Zhao C, Ye L, Zhang X. Depression of tumorigenesis mediated by human mesenchymal stem cells in a model of hepatoma cells.. Cell Res<\/p>\n<\/p>\n

\u3000\u3000Ye LH, Dong N\uff0cWang Q\uff0cXu ZL\uff0cCai N\uff0cWang HH\uff0cZhang X. Progressive changes in hepatoma cells stably transfected with hepatitis B virus X gene. Intervirology<\/p>\n<\/p>\n

\u3000\u3000Zhang H, Shan C, Li N, Zhang X, Zhang X, Xu F, Zhang S, Qiu L, Ye L, Zhang X. Identification of a natural mutant of HBV X protein truncated 27 amino acids at COOH-terminal and it. Acta Pharmacologica Sinica<\/p>\n<\/p>\n

\u3000\u3000Qiao L, Zhao T, Wang F, Shan C, Ye L, Zhang X. NF-\u03baB downregulation maybe involved the depression of proliferation of tumor cells mediated by human mesenchymal stem cells. . Acta Pharmacologica Sinica,<\/p>\n<\/p>\n

\u3000\u3000Wang F, Sha L, Ye L*, Zhang X. Promotion of cell proliferation by HBXIP via upregulation of human telomerase reverse transcriptase in human mesenchymal stem cells. . Acta Pharmacologica Sinica<\/p>\n<\/p>\n

\u3000\u3000\u5f20\u70dc\uff0c\u53f6\u4e3d\u8679\uff0c\u5f20\u6653\u4e1c. \u9aa8\u6865\u86cb\u767d\u901a\u8fc7NF-kB\u4e0a\u8c03\u9499\u86cb\u767d\u9176\u5c0f\u4e9a\u57fa1\u4fc3\u8fdb\u809d\u764c\u7ec6\u80de\u8fc1\u79fb. \u751f\u7269\u5316\u5b66\u4e0e\u751f\u7269\u7269\u7406\u8fdb\u5c55<\/p>\n<\/p>\n

\u3000\u3000Cui WJ, Liu Y, Zhou XL, Wang FZ, Zhang XD, Ye LH. Myosin light chain kinase is responsible for high proliferative ability of breast cancer cells via anti-apoptosis involving p38 pathway. Acta Pharmacol Sin.<\/p>\n<\/p>\n

\u3000\u3000Zhang X, Ye LH, Zhang XD. A mutant of hepatitis B virus X protein (HBx?127) enhances cell migration via osteopontin (OPN) invo. Acta Pharmacol Sin.<\/p>\n<\/p>\n

\u3000\u3000Zhang F, Wang Q, Ye LH, Feng YM, Zhang XD. Hepatitis B virus X protein upregulates expression of calpain small subunit 1 via nuclear factor-kap. J Med Virol.<\/p>\n<\/p>\n

\u3000\u3000Shan C, Xu FQ, Zhang S, You JC, You XN, Qiu LY, Zheng J, Ye LH, Zhang XD. Hepatitis B virus X protein promotes liver cell proliferation via a positive cascade loop involving arachidonic acid metabolism and p-ERK1\/2. Cell Res.<\/p>\n<\/p>\n

\u3000\u3000Wang Q, Zhang WY, Ye LH, Zhang XD. A mutant of HBx (HBx\u0394127) promotes hepatoma cell growth via sterol regulatory element binding protein 1c involving 5-lipoxygenase. Acta Pharmacol Sin.<\/p>\n<\/p>\n

\u3000\u3000Wang Q, Zhang W, Liu Q, Zhang X, Lv N, Ye L, Zhang XD. A Mutant of Hepatitis B Virus X Protein (HBxDelta127) Promotes Cell Growth through A Positive Feedba. Neoplasia<\/p>\n<\/p>\n

\u3000\u3000Zhou XL, Qin XR, Zhang XD, Ye LH. Downregulation of Dickkopf-1 is responsible for high proliferation of breast cancer cells via losing control of Wnt\/\u03b2-catenin signaling. Acta Pharmacol Sin.<\/p>\n<\/p>\n

\u3000\u3000Cui WJ, Zhang YW, Hu N, Shan CL, Zhang S, Zhang WY, Zhang XD, Ye LH. MiRNA-520b and miR-520e sensitize breast cancer cells to complement attack via directly targeting 3u2032. Cancer Biol Ther.<\/p>\n<\/p>\n

\u3000\u3000\u5f20\u70dc\uff0c\u53f6\u4e3d\u8679\uff0c\u5f20\u6653\u4e1c. \u4e59\u809d\u75c5\u6bd2X\u86cb\u767d\u901a\u8fc7\u9aa8\u6865\u86cb\u767dOPN\u4fc3\u8fdb\u809d\u764c\u7ec6\u80de\u8fc1\u79fb. \u4e2d\u56fd\u751f\u5316\u4e0e\u5206\u5b50\u751f\u7269\u5b66\u5b66\u62a526-4-<\/p>\n<\/p>\n

\u3000\u3000\u5468\u6653\u96f7\uff0c\u5f20\u6653\u4e1c,\u53f6\u4e3d\u8679. DKK-1\u901a\u8fc7\u4e0a\u8c03nm23\u8868\u8fbe\u6291\u5236\u4e73\u817a\u764c\u7ec6\u80de\u8fc1\u79fb\u3002. \u4e2d\u56fd\u751f\u5316\u4e0e\u5206\u5b50\u751f\u7269\u5b66\u5b66\u62a5 26-2-<\/p>\n<\/p>\n

\u3000\u3000Wang Q, Zhang T, Ye LH*, Wang WH, Zhang XD.. Analysis of hepatitis B virus X gene (HBx) mutants in tissues of patients suffered from hepatocellular carcinoma inChina. Cancer Epidemiology –.<\/p>\n<\/p>\n

\u3000\u3000Zhang S, Shan CL, Kong GY, Du YM, Ye LH*, Zhang XD*. MicroRNA-520e suppresses growth of hepatoma cells by targeting the NF-\u03baB-inducing kinase (NIK). Oncogene<\/p>\n<\/p>\n

\u3000\u3000Kong G, Zhang J, Zhang S, Shan C, Ye LH*, Zhang XD*. Upregulated MicroRNA-29a by Hepatitis B Virus X Protein Enhances Hepatoma Cell Migration by Targetin. PLoS One 6-5<\/p>\n<\/p>\n

\u3000\u3000Kong GY, Zhang JP, Zhang S, Shan CL, Ye LH*, Zhang XD*.. Hepatitis B virus X protein promotes hepatoma cell proliferation via upregulation of MEKK2. Acta Pharmacol Sin.<\/p>\n<\/p>\n

\u3000\u3000\u5f20\u714a;\u53f6\u4e3d\u8679*;\u5f20\u6653\u4e1c*. Osteopontin(OPN) Upregulates Calpain Small Subunit 1(Capn4) via Nuclear Facter-kappa B in Promotion of Hepatoma Cell Migration. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 37-5-534.2010-1-1<\/p>\n<\/p>\n

\u3000\u3000\u5c24\u5609\u742e\uff0c\u7c73\u8fbe\uff0c\u5468\u6653\u96f7\uff0c\u4e54\u73b2\uff0c\u5f20\u822a\uff0c\u5f20\u6653\u4e1c*\uff0c\u53f6\u4e3d\u8679*. A Positive Feedback between Activated Extracellularly Regulated Kinase and Cyclooxygenase\/Lipoxygenase Maintains Proliferation and Migration of Breast Cancer Cells. ENDOCRINOLOGY 150-4-1607-1617.2009-1-1<\/p>\n<\/p>\n

\u3000\u3000Zhang Xue-Zhi; Shan Chang-Liang; Ye Li-Hong; Zhang Xiao-Dong. Advantages of RNA interference in anti-hepatitis B virus therapy. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 35-6-631.2008-1-1<\/p>\n<\/p>\n

\u3000\u3000Nan HU, Yu LI, Yu ZHAO, Qi WANG, Jia-cong YOU, Xiao-dong ZHANG, Li-hong YE. A novel positive feedback loop involving FASN\/p-ERK1\/2\/5-LOX\/LTB4\/FASN sustains high growth of breast cancer cells. ACTA PHARMACOLOGICA SINICA 32–921-929.2011-1-1<\/p>\n<\/p>\n

\u3000\u3000Changliang Shan, Shuai Zhang, Wenjing Cui, Xiaona You, Guangyao Kong, Yumei Du, Liyan Qiu, Lihong Yeand Xiaodong Zhang. Hepatitis B virus X protein activates CD59 involving DNA binding and let-7i in protection of hepatoma and hepatic cells from complement attack. Carcinogenesis<\/p>\n<\/p>\n

\u3000\u3000Hu N, Zhang J, Cui W, Kong G, Zhang S, Yue L, Bai X, Zhang Z, Zhang W, Zhang X, Ye L.. miR-520b Regulates Migration of Breast Cancer Cells by Targeting Hepatitis B X-interacting Protein and Interleukin-8. J Biol Chem<\/p>\n<\/p>\n

\u3000\u3000\u5f20\u6d9b,\u5f20\u4fca\u840d,\u7531\u6653\u5a1c,\u5218\u8fc1,\u675c\u7389\u6885,\u9ad8\u7389\u6069,\u5c71\u957f\u4eae,\u5b54\u5149\u8000,\u53f6\u4e3d\u8679\uff0c\u5f20\u6653\u4e1c.Hepatitis B Virus X Protein (HBx) Modulates OncogeneYAPvia CREB to Promote Growth of Hepatoma Cells. . Hepatology<\/p>\n<\/p>\n

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\u3000\u3000Zhang X, You X, Wang Q, Zhang T, Du Y, Lv N, Zhang Z, Zhang S, Shan C, Ye LH, Zhang XD. Hepatitis B virus X protein promotes cell migration via multiple cross-talk cascade loops involving . PLoS One 2012;7(2):e<\/p>\n<\/p>\n

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\u3000\u3000Cui W, Zhao Y, Shan C, Kong G, Hu N, Zhang Y, Zhang S, Zhang W, Zhang XD, Ye LH. HBXIP upregulates CD46, CD55 and CD59 through ERK1\/2\/NF-\u03baB signaling to protect breast cancer cells . FEBS Letters<\/p>\n<\/p>\n

\u3000\u3000Zhao Y, Wang W, Wang Q, Zhang XD, Ye LH. Lipid metabolism enzyme 5-LOX and its metabolite LTB4 are capable of activating transcription factor. Biochem Biophys Res Commun.<\/p>\n<\/p>\n

\u3000\u3000Zhang X, You XN, Li N, Zhang WY, Gagos S, Wang Q, Banos A, Cai N, Zhang HK, Zhang H, Zhang XZ, Shan CL, Qiu LY, Zhang S, Lv N, Chen MS, Du YM, Xia JC, Ye LH*, Zhang XD*. Involvement of hepatitis B virus X gene (HBx) integration in hepatocarcinogenesis via a recombination of HBx\/Alu core sequence\/subtelomeric DNA. FEBS Letters<\/p>\n<\/p>\n

\u3000\u3000Liu SP, Li LL, Zhang YY, Zhang YW, Zhao Y, Lin ZH, Zhang XD*, Ye LH*. HBXIP upregulates s100a4 via stat4 and pten to promote growth and migration of breast cancer cells. J Biol Chem<\/p>\n<\/p>\n

\u3000\u3000 <\/p>\n<\/p>\n

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