\t\u6765\u6e90\uff1a21\u4e16\u7eaa\u7ecf\u6d4e\u62a5\u9053<\/p>\n
\t\u3000\u300021\u4e16\u7eaa\u7ecf\u6d4e\u62a5\u9053\u8bb0\u8005 \u5b63\u5a9b\u5a9b \u4e0a\u6d77\u62a5\u9053 \u968f\u7740\u6e24\u5065\u810a\u9ad3\u6027\u808c\u840e\u7f29\u75c7\uff08SMA\uff09\u6cbb\u7597\u836f\u7269\u8bfa\u897f\u90a3\u751f\u94a0\u88ab\u7eb3\u51652021\u5e74\u65b0\u7248\u533b\u4fdd\u836f\u54c1\u76ee\u5f55\u540e\uff0c\u8bfa\u534e\u4e5f\u52a0\u5feb\u4e86\u5728\u534e\u5f15\u5165SMA\u521b\u65b0\u836f\u7269\u7684\u6b65\u4f10\u3002<\/p>\n
\t\u3000\u3000\u8fd1\u65e5\uff0c\u636e\u4e2d\u56fd\u56fd\u5bb6\u836f\u76d1\u5c40\u836f\u54c1\u5ba1\u8bc4\u4e2d\u5fc3\uff08CDE\uff09\u516c\u793a\uff0c\u8bfa\u534e\u65d7\u4e0b\u6cbb\u7597SMA\u7684AAV\u57fa\u56e0\u6cbb\u7597\u836f\u7269Zolgensma\uff08OAV101\u6ce8\u5c04\u6db2\uff09\u5728\u4e2d\u56fd\u9012\u4ea4\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u5df2\u83b7\u5f97\u4e34\u5e8a\u8bd5\u9a8c\u9ed8\u793a\u8bb8\u53ef\u3002\u6b64\u524d2021\u5e7410\u670821\u65e5\uff0c\u8be5\u836f\u7269\u7684\u4e34\u5e8a\u8bd5\u9a8c\u7533\u8bf7\u83b7\u5f97\u53d7\u7406\u3002<\/p>\n
\t\u3000\u3000\u636e\u516c\u5f00\u6d88\u606f\u663e\u793a\uff0c\u8bfa\u534e\u7684Zolgensma\u662f\u5168\u7403\u9996\u4e2a\u6cbb\u7597\u810a\u9ad3\u6027\u808c\u840e\u7f29\u75c7\u7684\u57fa\u56e0\u7597\u6cd5\uff0c\u56fd\u5916\u5b9a\u4ef7212.5\u4e07\u7f8e\u5143\uff08\u6298\u5408\u4eba\u6c11\u5e01\u7ea61358\u4e07\u5143\uff09\uff0c\u4e5f\u88ab\u79f0\u4e3a“\u53f2\u4e0a\u6700\u8d35\u836f\u7269”\uff0c\u4e0d\u8fc7\uff0cZolgensma\u53ea\u9700\u6ce8\u5c04\u4e00\u6b21\u5373\u53ef\u3002\u76ee\u524dZolgensma\u5df2\u7ecf\u5728\u5168\u7403\u8fd140\u4e2a\u56fd\u5bb6\u548c\u5730\u533a\u83b7\u6279\u3002\u5176\u4e2d\uff0cZolgensma\u4e8e2020\u5e74\u88ab\u65e5\u672c\u7eb3\u5165\u533b\u4fdd\uff0c\u60a3\u8005\u53ea\u9700\u652f\u4ed830%\u8d39\u7528\uff1b\u540e\u57282021\u5e743\u6708\u88ab\u82f1\u56fd\u7eb3\u5165\u56fd\u5bb6\u533b\u7597\u670d\u52a1\u4f53\u7cfb\u3002<\/p>\n
\t\u3000\u3000\u76ee\u524d\uff0c\u5168\u7403\u4ec5\u6279\u51c6\u6e24\u5065\u3001\u8bfa\u534e\u3001\u7f57\u6c0f\u4e09\u6b3eSMA\u6cbb\u7597\u836f\u7269\u3002\u9664\u8bfa\u534eZolgensma\u521a\u5728\u4e2d\u56fd\u83b7\u6279\u4e34\u5e8a\u8bd5\u9a8c\u5916\uff0c\u7f57\u6c0f\u7684Evrysdi\u4e5f\u4e8e2021\u5e746\u6708\u5728\u4e2d\u56fd\u83b7\u6279\u4e0a\u5e02\uff0c\u6210\u4e3a\u9996\u4e2a\u5728\u4e2d\u56fd\u83b7\u6279\u6cbb\u7597SMA\u7684\u53e3\u670d\u6cbb\u7597\u836f\u7269\u3002\u6b64\u5916\uff0c\u5168\u7403\u8303\u56f4\u5185SMA\u9886\u57df\u76f8\u5173\u5728\u7814\u836f\u7269\u4e5f\u6709\u5341\u51e0\u6b3e\u5904\u5728\u4e0d\u540c\u7684\u4e34\u5e8a\u9636\u6bb5\u3002<\/p>\n
\t\u3000\u3000SMA\u60a3\u8005\u9762\u4e34\u8bca\u65ad\u96be\u9898<\/p>\n
\t\u3000\u3000\u810a\u9ad3\u6027\u808c\u840e\u7f29\u75c7\uff08SMA\uff09\u662f\u4e00\u79cd\u7f55\u89c1\u7684\u5e38\u67d3\u8272\u4f53\u9690\u6027\u9057\u4f20\u6027\u795e\u7ecf\u808c\u8089\u75be\u75c5\uff0c\u5176\u7279\u70b9\u662f\u8fdb\u884c\u6027\u3001\u4f7f\u4eba\u8870\u5f31\u7684\u808c\u8089\u840e\u7f29\u3001\u65e0\u529b\u3002SMA\u60a3\u513f\u4e3b\u8981\u53d1\u75c5\u4e8e\u5a74\u5e7c\u513f\uff0c\u53ef\u80fd\u8868\u73b0\u4e3a\u808c\u5f20\u529b\u51cf\u9000\uff0c\u5934\u90e8\u63a7\u5236\u4e0d\u826f\u3001“\u86d9\u817f”\u6837\u59ff\u52bf\u3001\u547c\u5438\u56f0\u96be\u3001\u53d1\u80b2\u8fdf\u7f13\u3001\u810a\u67f1\u4fa7\u51f8\u6216\u5173\u8282\u631b\u7f29\u7b49\u75c7\u72b6\u3002\u968f\u7740\u75be\u75c5\u7684\u8fdb\u5c55\uff0c\u8fd0\u52a8\u529f\u80fd\u9010\u6e10\u51cf\u9000\u3002<\/p>\n
\t\u3000\u3000SMA\u662f\u5bfc\u81f4\u4e24\u5c81\u4ee5\u4e0b\u5a74\u513f\u6b7b\u4ea1\u7684\u9996\u8981\u9057\u4f20\u75c5\u56e0\u7d20\uff0c\u4e25\u91cd\u5f71\u54cd\u60a3\u8005\u53ca\u770b\u62a4\u8005\u751f\u6d3b\u8d28\u91cf\uff0c\u4e14\u6b64\u524d\u60a3\u8005\u4e00\u76f4\u9762\u4e34\u65e0\u836f\u53ef\u7528\u7684\u7a98\u5883\u3002<\/p>\n
\t\u3000\u3000\u6765\u81ea\u6d59\u6c5f\u7684\u73cd\u59ae\u5c31\u662f\u672a\u8fdb\u884c\u4ea7\u524d\u7b5b\u67e5\u800c\u88ab\u751f\u4e0b\u6765\u7684SMA\u60a3\u8005\u3002\u5728\u73cd\u59ae1\u5c81\u591a\u65f6\uff0c\u5bb6\u4eba\u53d1\u73b0\u5979\u59cb\u7ec8\u4e0d\u80af\u4e0b\u5730\u8d70\u8def\u3002\u7ecf\u533b\u9662\u68c0\u67e5\uff0c\u5979\u88ab\u786e\u8bca\u4e3a\u7f55\u89c1\u75c5SMA\u3002“\u4f60\u5973\u513f\u6700\u591a\u6d3b\u5230\u56db\u5c81\uff0c\u56de\u5bb6\u597d\u597d\u7167\u987e\u5427\u3002”\u533b\u751f\u7684\u4e00\u756a\u8bdd\uff0c\u4ee4\u73cd\u59ae\u7684\u7236\u4eb2\u5305\u5b97\u950b\u4e00\u4e0b\u5b50\u8499\u4e86\u3002\u4ed6\u5e26\u7740\u73cd\u59ae\u8d70\u904d\u6d59\u6c5f\u5404\u5927\u533b\u9662\uff0c\u5954\u8d70\u5168\u56fd\u6c42\u533b\uff0c\u4e00\u6b21\u6b21\u88ab\u544a\u77e5\u76f8\u540c\u7684\u7ed3\u679c\u3002<\/p>\n
\t\u3000\u3000\u6700\u7ec8\uff0c\u5305\u5b97\u950b\u82b1\u5149\u4e86\u6240\u6709\u79ef\u84c4\uff0c\u751a\u81f3\u80cc\u4e0a\u4e8640\u591a\u4e07\u5143\u7684\u503a\u52a1\u3002\u4f46\u5973\u513f\u4e0d\u4ec5\u6ca1\u6709\u4e1d\u6beb\u597d\u8f6c\uff0c\u751a\u81f3\uff0c\u4e0b\u80a2\u6e10\u6e10\u5931\u53bb\u8fd0\u52a8\u80fd\u529b\uff0c\u4e0a\u80a2\u7684\u8fd0\u52a8\u80fd\u529b\u4e5f\u5728\u53d8\u5f31\uff0c\u810a\u690e\u53d8\u5f62\u3002<\/p>\n
\t\u3000\u3000\u5728\u6f2b\u957f\u7684\u6cbb\u7597\u751f\u6daf\u4e2d\uff0c\u5305\u5b97\u950b\u77e5\u9053\u8ba9\u5973\u513f\u597d\u8f6c\u5df2\u65e0\u53ef\u80fd\uff0c\u4ed6\u4eec\u5728\u54a8\u8be2\u5f53\u5730\u533b\u751f\u540e\u5f97\u77e5\uff0c\u82e5\u518d\u751f\u4e2a\u5b69\u5b50\uff0c\u60a3\u6b64\u75c5\u7684\u51e0\u7387\u4ec5\u4e3a25%\u3002\u5982\u679c\u8fd9\u4e2a\u5b69\u5b50\u5065\u5eb7\uff0c\u5c31\u80fd\u5728\u4ed6\u4eec\u767e\u5e74\u4e4b\u540e\u7167\u987e\u73cd\u59ae\u3002\u592b\u59bb\u4fe9\u51b3\u5b9a\u4e3a\u4e86\u73cd\u59ae\u8d4c\u4e00\u628a\u3002<\/p>\n
\t\u3000\u3000\u4e8e\u662f\uff0c2008\u5e74\uff0c\u513f\u5b50\u5305\u5965\u5065\u51fa\u751f\uff0c\u4e0d\u5e78\u7684\u662f\uff0c\u60b2\u5267\u91cd\u6f14\uff1a2009\u5e74\uff0c\u5c0f\u5965\u5065\u4ecd\u88ab\u8bca\u65ad\u4e3aSMA\u3002<\/p>\n
\t\u3000\u3000\u800c\u592b\u5987\u4fe9\u5728\u751f\u4e0b\u513f\u5b50\u540e\u624d\u5f97\u77e5\uff0c\u7ea650\u4eba\u4e2d\u5c31\u6709\u4e00\u4f4dSMA\u81f4\u75c5\u57fa\u56e0\u643a\u5e26\u8005\uff0c\u4e8c\u80ce\u4ea7\u68c0\u53ca\u6709\u5bb6\u65cf\u75c5\u53f2\u7684\u9ad8\u5371\u4eba\u7fa4\u643a\u5e26\u8005\u7b5b\u67e5\u53ef\u6709\u6548\u963b\u65ad\u65b0\u53d1\u75c5\u4f8b\u3002\u53ef\u592b\u5987\u4fe9\u90fd\u662f\u519c\u6c11\uff0c\u4ed6\u4eec\u6839\u672c\u4e0d\u77e5\u9053\u8be5\u75c5\u53ef\u4ee5\u505a\u4ea7\u524d\u57fa\u56e0\u68c0\u6d4b\uff0c\u4f55\u51b5\u5f7c\u65f6\u5f53\u5730\u4e5f\u6ca1\u6709\u76f8\u5e94\u7684\u68c0\u6d4b\u673a\u6784\u3002<\/p>\n
\t\u3000\u3000\u4e2d\u5357\u5927\u5b66\u6e58\u96c5\u533b\u9662\u513f\u79d1\u4e3b\u4efb\u533b\u5e08\u5f6d\u955c\u6b64\u524d\u5728\u63a5\u53d7\u5a92\u4f53\u91c7\u8bbf\u65f6\u8868\u793a\uff0cSMA\u7684\u53d1\u75c5\u7387\uff0c\u7ea6\u4e3a6000\u81f310000\u5206\u4e4b\u4e00\u3002\u636e\u6b64\u4f30\u7b97\uff0c\u4e2d\u56fd\u53ef\u80fd\u670920000\u81f330000\u7684\u60a3\u8005\u3002<\/p>\n
\t\u3000\u3000“\u8fd9\u4e2a\u7f55\u89c1\u75c5\u8bef\u8bca\u7387\u6781\u9ad8\u3002\u65b0\u751f\u513f\u60a3\u513f\u7531\u4e8e\u808c\u8089\u6ca1\u6709\u529b\u6c14\uff0c\u53ef\u80fd\u4f1a\u88ab\u8bef\u8bca\u4e3a\u7f3a\u8840\u7f3a\u6c27\u6027\u8111\u75c5\uff0c\u6216\u8005\u56e0\u5168\u8eab\u6ca1\u6709\u529b\u6c14\uff0c\u8bef\u8bca\u4e3a\u8111\u762b\u6216\u8fd0\u52a8\u969c\u788d\u3002\u6b64\u5916\uff0c\u8be5\u7f55\u89c1\u75c5\u7531\u4e8e\u5e38\u6709\u80ba\u90e8\u75be\u75c5\uff0c\u547c\u5438\u808c\u6ca1\u6709\u529b\u6c14\uff0c\u5728\u91cd\u75c7ICU\u53ef\u80fd\u88ab\u8bca\u65ad\u4e3a\u91cd\u75c7\u80ba\u708e\u76f4\u81f3\u6b7b\u4ea1\u3002\u4f46\u662f\u8be5\u75be\u75c5\u4e5f\u6709\u5b83\u81ea\u5df1\u7684\u7279\u70b9\uff0c\u60a3\u513f\u867d\u7136\u808c\u65e0\u529b\uff0c\u4f46\u662f\u773c\u795e\u975e\u5e38\u597d\uff0c\u5982\u679c\u60f3\u5230\u4e86\u8fd9\u4e2a\u75c5\uff0c\u8bca\u65ad\u5e76\u4e0d\u56f0\u96be\u3002\u6572\u4e00\u4e0b\u819d\u8171\u53cd\u5c04\u4e0d\u80fd\u5f15\u51fa\uff0c\u505a\u4e2a\u808c\u7535\u56fe\uff0c\u6216\u8005\u57fa\u56e0\u68c0\u6d4b\uff0c\u4e5f\u5c31\u80fd\u5f88\u5feb\u80fd\u5e2e\u52a9\u60a3\u8005\u660e\u786e\u8bca\u65ad\u3002”\u5f6d\u955c\u6559\u6388\u8bf4\u3002<\/p>\n
\t\u3000\u30001991\u5e74\u56fd\u9645\u810a\u9ad3\u808c\u840e\u7f29\u8054\u5408\u4f1a\u786e\u8ba4SMA\u5206\u578b\u3002\u6839\u636e\u8fd0\u52a8\u529f\u80fd\u7684\u6700\u9ad8\u6c34\u5e73\u548c\u53d1\u75c5\u5e74\u9f84\u4e3b\u8981\u5206\u4e3aI\u3001II\u3001III\u578b\u3002\u6b64\u5916\u8fd8\u6709\u6210\u4eba\u53d1\u75c5\u7684IV\u578b\uff0c\u4ee5\u53ca\u4ea7\u524d\u53d1\u75c5\u548c\u6570\u5468\u5185\u6b7b\u4ea1\u76840\u578b\u3002<\/p>\n
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